The Regiment was organized at Fort Mitchell in the summer of IS61 and was immediately ordered into Virginia. Joining the main Army Manassas, the Fifteenth was brigaded with the 21st Georgia, the 21st North Carolina and the 16th Mississippi under General G. B. Crittenden from Kentucky. General I.R. Trimble replaced General Crittenden as Brigade Commander in December of 1861.
While the rest of the Army moved to Yorktown, Virginia, the Fifteenth remained in the Shenandoah Valley as part of General T. J. Jackson’s Corps. The Regiment was engaged at Front Royal and suffered light casualties at Winchester. The Fifteenth then fought at Cross Keys and suffered 9 killed and 33 wounded out of 425 men. The Regiment then marched toward Richmond as a part of General Jackson’s flanking movement against Union General G. B. McClellan’s Peninsula Campaign. The Fifteenth then entered the Battle of Gaines’ Mill (First Cold Harbor) with 412 men and lost 34 killed and 110 wounded. Five days later, the Regiment came under artillery fire at Malvern Hill and suffered light casualties.
The Fifteenth was a part of General R. E. Lee’s Maryland Campaign and was engaged at Hazel River and Manassas Junction with a loss of 6 killed and 22 wounded. A day or two later, the Regiment fought in the Second Battle of Manassas and lost 21 killed and 91 wounded out of a total of 440 men. At Chantilly, the Fifteenth lost 4 killed and 14 wounded. The Regiment then took part in the capture of Harper’s Ferry, Virginia with no losses. The Fifteenth entered the Battle of Sharpsburg, Maryland (Antietam) with 300 men and suffered losses of 9 killed and 75 wounded.
The Regiment then fought in the defensive Battle of Fredericksburg, Virginia while suffering casualties of 1 killed and 34 wounded.
The Fifteenth Alabama was then brigaded under General Law along with the 4th, the 44th, the 47th and the 48th Alabama Regiments. This Brigade was a part of General Longstreet’s Corps and participated in his Suffolk, Virginia operations losing 4 killed and 18 wounded.
The Fifteenth was then a part of General R E. Lee’s Gettysburg Campaign. The Regiment was a part of the assault on the Union left by General Hood’s Division. Losses were 72 killed, 190 wounded and 81 missing out of 644 men involved in the fight. On the retreat from Pennsylvania, the Regiment suffered light casualties at Battle Mountain.
The Fifteenth was then transferred to the Army of Tennessee in the Western Theatre. At the Battle of Chickamauga in northwestern Georgia, the regiment lost 19 killed and 123 wounded from a total of 425 men. In fights at Brown’s Ferry and Lookout Valley in Tennessee, 15 men were killed and 40 were wounded. In operations against Union-occupied Knoxville, the Regiment lost 6 killed and 21 wounded. The Fifteenth then was shelled at Bean’s Station, Tennessee.
The Regiment was then transferred back to the Army of Northern Virginia in the Eastern Theatre. The Fifteenth took 450 men into the battles of The Wilderness and Spotsylvania Court House and suffered casualties of 18 killed and 48 wounded. The Regiment then fought at Hanover Junction and Second Cold Harbor losing 6 killed and 16 wounded. The “last ditch” defense of Petersburg, Virginia was the Fifteenth’s next fight. At Deep Bottom, the Fifteenth lost a third of its 275 men. At Fussell’s Mill, the Regiment lost 13 killed and 90 wounded. The Fifteenth Regiment of Alabama Volunteers surrendered 170 men at Appomattox. Out of a total regimental roll of 1633 men, 260 fell in battle, 440 died in the service of other causes and 231 were transferred or discharged.